Localization of streptococcal membranes in mouse tissues by an immunofluorescence method

Summary The direct immunofluorescent method was used to study the distribution and duration of persistence of the streptococcus membranes in the tissues of mice after their subcutaneous (paratracheal) and intravenous injection. It has been shown that in paratracheal injection of the streptococcus membranes the latter are discovered only in the cellular tissue at the site of their entry. At first they are absorbed by neutrophils and then accumulated in the cytoplasm of the macrophages where they are retained for more than 2 months. In the case of intravenous injection of streptococcus membranes one observes their selective absorption by the reticulo-histiocytic cells of the liver and spleen.(Presented by Active Member of the Academy of Medical Sciences of the USSR A. I. Nesterov) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 61, No. 5, pp. 84–87, May, 1966