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| 表没食子儿茶素没食子酸酯固体粉末的稳定性考察 | |
| 引用本文： | 郭震,林坚涛,黄韧,廖艳,王敏,沈佳娜,吴玉娥. 表没食子儿茶素没食子酸酯固体粉末的稳定性考察[J]. 中国药房, 2007, 18(25): 1973-1975 |
| 作者姓名： | 郭震 林坚涛 黄韧 廖艳 王敏 沈佳娜 吴玉娥 |
| 作者单位： | 1. 广东省实验动物监测所,广州市,510260;广东医学院药理教研室,湛江市,524023 2. 广东医学院药理教研室,湛江市,524023 3. 广东省实验动物监测所,广州市,510260 4. 广东海洋大学分析测试中心,湛江市,524025 |
| 基金项目： | 广东省中医药管理局资助项目 |
| 摘 要： | 目的:考察表没食子儿茶素没食子酸酯(EGCG)固体粉末的稳定性。方法:采用高效液相色谱法测定含量,按照《中国药典》相关规定对影响EGCG稳定性的因素进行研究。结果:EGCG检测浓度的线性范围为7.76～77.6μg·mL-1(r=0.9999);平均回收率为101.29%(RSD=0.76%);在强光、高温、高湿条件下,EGCG粉末颜色有不同程度的变化,但含量均无明显变化,也未见新的降解物质产生。结论:EGCG固体粉末的稳定性较好。 |
| 关 键 词： | 表没食子儿茶素没食子酸酯 固体粉末 高效液相色谱法 稳定性 |
| 文章编号： | 1001-0408（2007）25-1973-03 |
| 收稿时间： | 2006-10-23 |
| 修稿时间： | 2006-12-07 |
Stability of Epigallocatechin Gallate Solid Powder |
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| GUO Zhen,HUANG Ren,WANG Min,SHEN Jiana,WU Yu'e,LIN Jiantao,LIAO Yan. Stability of Epigallocatechin Gallate Solid Powder[J]. China Pharmacy, 2007, 18(25): 1973-1975 | |
| Authors: | GUO Zhen HUANG Ren WANG Min SHEN Jiana WU Yu'e LIN Jiantao LIAO Yan |
| Abstract: | OBJECTIVE: To investigate the stability of epigallocatechin gallate ( EGCG) powder. METHODS: The content of the sample was determined by HPLC, and the factors affecting the stability of EGCG were studied according to the related guideline stated in China Pharmacopeia. RESULTS: The linear range of EGCG was 7. 76～ 77. 6μ g· mL- 1( r=0. 999 9) , with average recovery at 101. 29% ( RSD=0. 76% ) . Exposed to strong illumination, high temperature and high humidity, the color of EGCG powder suffered variant degree of change, but its content experienced no marked change, and no new degraded substances was noted. CONCLUSION: EGCG powder had a sound stability. |
| Keywords: | Epigallocatechin gallate Solid powder HPLC Stability |
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