| 奈达铂联合替加氟治疗晚期食管癌的临床观察 |
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| 作者单位： | Lianggeng Xiong(Department of Medical Ontology, The Second People Hospital of Dazhou, Dazhou 635000, China);Youshan Li(Thoracic Surgical Department, The Second People Hospital of Dazhou, Dazhou 635000, China)
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| 摘 要： |
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| 关 键 词： | 化疗治疗 晚期食管癌 5-Fu方案 胃肠功能紊乱 中晚期食管 对照组 氟脲嘧啶 骨髓抑制 |
| 收稿时间： | 28 November 2010 |
Short-term effects of nedaplatin plus futraful chemotherapy in treatment of advanced esophageal carcinoma |
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| Authors: | Lianggeng Xiong Youshan Li |
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| Institution: | [1]Department of Medical Oncology, The Second People Hospital of Dazhou, Dazhou 635000, China [2]Thoracic Surgical Department, The Second People Hospital of Dazhou, Dazhou 635000, China |
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| Abstract: | Objective:To observe the efficacy and the side effects of nedaplatin with futraful in the treatment of advanced esophageal carcinoma. Methods:Observing group NDP/FT-207 regimen:given nedaplatin 80-100 mg/m2 on day 1 and futraful 500-600 mg/m2 on day 1 to 5;control group:DDP/5-Fu regimen received cisplatin 80-100 mg/m2 on day 1 and 5-Fluorouracil 500-750 mg/m2 on day 1 to 5. In both groups per 28 days was a cycle, 2-3 cycles were one course. Results:Response and toxicity could be assessed in all the 78 patients, 42 patients were in observing group, the other 36 patients were in control group. The response rate of patients treated by NDP/FT-207 and DDP/5-Fu were 57.1% (24/42) and 50% (18/36) respectively. The two groups have no significant difference. The toxicities as gastrointestinal disorders and myelosuppression in observing group was lighter than those in control group. Conclusion:The combination of NDP and FT-207 is a safer and effective regimen. |
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| Keywords: | esophageal carcinoma nedaplatin futraful |
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