| 家兔隔区和伏核内钙、镁离子对抗电针镇痛与吗啡镇痛 |
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| 引用本文： | 金文泉,周仲福,韩济生.家兔隔区和伏核内钙、镁离子对抗电针镇痛与吗啡镇痛[J].药学学报,1985(10). |
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| 作者姓名： | 金文泉 周仲福 韩济生 |
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| 作者单位： | 北京医科大学生理教研室，北京医科大学生理教研室，北京医科大学生理教研室 重庆医学院生理教研室 |
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| 摘 要： | 本文通过脑内慢性埋植套管向家兔一侧隔区或伏核内注射微量(10 nmol)CaCl_2或MgCl_2,可显著对抗吗啡镇痛和电针镇痛。注入核外则无效。家兔一侧隔区或伏核内注入阳离子螯合剂CDTA(20 nmol)加强吗啡镇痛和电针镇痛。文中就Ca~(2 ),Mg~(2 )作用的相似性,电针镇痛与吗啡镇痛机理的相似性,以及伏核和隔区在上述镇痛中的重要性进行了讨论。
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| 关 键 词： | 氯化钙 氯化镁 整合剂 吗啡 电针 镇痛 |
CALCIUM AND MAGNESIUM IONS IN SEPTUM AND NUCLEUS ACCUMBENS OF THE RABBIT ARE ANTAGONISTIC TO ACUPUNCTURE ANALGESIA AND MORPHINE ANALGESIA |
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| JIN Wen-Ouan,ZHOU Zhong-Fu and HAN Ji-Sheng.CALCIUM AND MAGNESIUM IONS IN SEPTUM AND NUCLEUS ACCUMBENS OF THE RABBIT ARE ANTAGONISTIC TO ACUPUNCTURE ANALGESIA AND MORPHINE ANALGESIA[J].Acta Pharmaceutica Sinica,1985(10). |
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| Authors: | JIN Wen-Ouan ZHOU Zhong-Fu and HAN Ji-Sheng |
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| Abstract: | Unilateral microinjection of CaCl_2 or MgCl_2 (10 nmol) into septum or nucleus accumbens of the rabbit via chronically implanted cannula markedly attenuated the analgesic effect induced by morphine or electroacupuncture (EA) stimulation. Microinjection of cation chelating agent CDTA (20 nmol) into septum or n. accumbens, on the contrary, potententiated EA and morphine analgesia. Injection into the vicinity of the nuclei was not effective. The results suggest (1) a similarity of the actions of Ca~(2 ) and Mg~(2 ) in antagonizing EA and morphine effect, (2) a similarity of the mechanisms for EA and morphine analgesia, and (3) the importance of septum and nucleus accumbens in mediating EA and morphine analgesia. |
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| Keywords: | Calcium chloride Magnesium chloride Chelating agent Morphine Electroacupuncture Analgesia |
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