甜瓜蒂化学成分的分离与鉴定

目的研究甜瓜蒂的化学成分。方法采用硅胶、ODS、凝胶、制备HPLC等多种色谱方法分离纯化,根据理化性质、波谱数据分析对分离得到的化合物进行结构鉴定。结果从甜瓜蒂中分离得到了7个化合物,分别鉴定为:粘霉烯醇(glutinol,1)、葫芦素B(cucurbitacin B,2)、葫芦素B-2-O-β-D-葡萄糖苷(2-O-β-D-glucopyranosy cucurbitacin B,3)、葫芦素D(cucurbitacin D,4)、(6S,9S)6-羟基-3-酮-α-紫罗兰醇-9-O-β-D-葡萄糖苷(6S,9S)6-hydroxyl-3-oxo-α-ionol-9-O-β-D-glucopyranoside,5]、尿嘧啶核苷(uridine,6)和β-D-葡萄糖乙苷(ethyl-β-D-glucopyranoside,7)。结论化合物1、5、7均为首次从甜瓜属植物中分离得到,化合物6为首次从甜瓜蒂植物中分离得到。

Isolation and identification of the chemical constituents of Pedicellus Melo

Objective To study the chemical composition of Pedicellus Melo. Methods The chemical constituents w ere isolated by various methods( silica gel,ODS and HPLC column chromatography) and their structures w ere elucidated by the analysis of spectral data and chemical properties. Results Seven compounds w ere obtained and identified as glutinol( 1),cucurbitacin B( 2),2-O-β-D-glucopyranosy cucurbitacin B( 3),cucurbitacin D( 4),( 6S,9S) 6-hydroxyl-3-oxo-α-ionol-9-O-β-D-glucopyranoside( 5),uridine( 6), ethyl-β-D-glucopyranoside( 7). Conclusions Compounds 1,5,7 are isolated from Cucumis genus for the first time,compounds 6 is isolated from the plant for the first time.