联用复方甘草酸苷治疗非酒精性脂肪肝炎的疗效观察

目的探讨联用复方甘草酸苷治疗非酒精性脂肪肝炎的临床疗效。方法将100例非酒精性脂肪肝炎患者随机分为对照组和治疗组各50例。对照组予多烯磷脂胶囊治疗8周；治疗组在使用易善复的基础上联用复方甘草酸苷片治疗8周。记录治疗前和治疗4周、8周后各项指标的变化，评价疗效。结果治疗组的总有效率为94％，对照组的总有效率为58％，两组比较差异有极显著性（P〈0．01、治疗组肝功能及血症指标变化较对照组明显（P〈0．01），且治疗8周后各项指标改善较治疗4周更为明显（P〈0．01l两组均未见明显不良反应。结论联用复方甘草酸苷片治疗非酒精性脂肪肝炎具有更好的护肝、降酶、降脂效果，并且安全、副作用小。

Clinical curative effect of combining with Compound Glycyrrhizin to treat non-alcoholic steatohepatitis

Objective To investigate the effect of Compound Glycyrrhizin (CG) and Polyene Phosphatidylcholine (PPC) to treat the patients of non-alcoholic steatohepatitis. Methods One hundred patients with noalcoholic steatohepatitis were divided into two groups randomly: therapy group (n=50) (received treatment with CG and PPC), and control group (n=50) was given only PPC. Both of two groups were all observed for 8 weeks. To calculate the clinical parameters before treatment and after treatment for 4 weeks and 8 weeks. The results were compared with each other. Results The total effective rate of therapy group was 94%; effective rate of control group was 58%; the study demonstrated that there were statistical differences between the two groups with respect to total effective rate(P＜ 0.01).After being treated with CG for 8 weeks, all the clinical parameters(ALT/AST/GGT/TC/TG) in the patients of therapy group had gone down markedly than those of control group(P＜ 0.01); in therapy group, all the value of the parameters after 8 weeks of treating reduced more statistically than that after 4 weeks of treating(P＜ 0.01).No toxicity had been found in both groups. Conclusion Combining with CG to treat non-alcoholic steatohepatitis has the effect of protecting liver and reducing enzyme and serum glucose safely and with less side effects.