乙型肝炎病毒前S1抗原检测的临床应用

目的 探讨乙型肝炎病毒前S1( PreSl)抗原检测在乙型肝炎诊断中的临床意义。方法 采用ELISA检测HBV血清标志物，取其中阳性标本254份，并按不同模式分为三组，分别检测各组乙肝前Sl抗原、HBV DNA和ALT并进行比较分析。结果 前S1抗原和HBV-DNA在HbsAg(+)HBeAg(+)HBcAb(+)的检...

The clinical value of hepatitis B virus Pre-S1 antigen detection

Objectives To explore the clinical significance of detection of HBV Pre-S1 antigen in the diagnosis of Hepatitis B. Methods 254 blood samples with positive HBV markers detected by ELISA were divided into three groups based on different modes. Pre-S 1 antigen, HBV DNA, and ALT were detected in each group and then were comparatively analyzed. Results The detection rates for PreS1 antigen and HBV-DNA were 77.5％ and 93.1％ in the group with HbsAg ( + ), HBeAg ( + ), and HBcAb ( + ), 45.7％ and 60.1％ in the group with HBsAg ( + ), HBeAb ( + ), and HBcAb ( + ); and 0％ and 14.3％ in the group with HBsAg (-), HBeAb ( + ), and HBcAb ( + ). The positive rate of PreSl was 64.4％ ( 116/180 ) and A LT abnormality rate was 61.1％ ( 110/180 ) in 180 samples with a HBVDNA copy number of greater than 500IU/ml, and they were 35.1％ and 33.8％ in 74 samples with a copy number of less than 500IU/ml, respectively. The positive of Pre-S1 antigen was increased with an elevation in HBV DNA viral load, but the ALT abnormality rate was not linearly associated with the increase in HBV DNA viral load. Conclusions HBV Pre-Sl antigen has a higher consistency with HBV-DNA, which has an important clinical value in the diagnosis of type B hepatitis and can provide more reliable referrence for judging viral replication in vivo and efficacy of treatment.