降粘、抗凝药物治疗2型糖尿病血液流变学指标的变化

目的：探讨降粘、抗凝药物蚓激酶、血塞通对2型糖尿病患者血糖及各项血液流变学指标的影响。方法：180例2型糖尿病患者随机分为对照组及蚓激酶、血塞通、蚓激酶＋血塞通3个治疗组，测定各组的空腹及3餐后2h血糖，并测定3个治疗组治疗前后的高切、低切全血粘度及血浆粘度、红细胞压积、纤维蛋白原5项血液流变学指标。结果：蚓激酶、血塞通、蚓激酶＋血塞通3个治疗组空腹及3餐后2h血糖均明显低于对照组（P〈0．05-0．01），3个治疗组治疗后高切、低切全血粘度及血浆粘度、红细胞压积、纤维蛋白原均明显低于治疗前（P〈0．05-0．01）。结论：降粘、抗凝药物蚓激酶、血塞通单独或联合应用均可改善2型糖尿病患者血液流变学障碍，促进血糖控制。

Changes of hemorrheology parameters of type 2 diabetes mellitus with antiagglutinate drugs

Objective: To investigate the effect of indexes of hemorrheology and BG in type 2 diabetes mellitus patients with using antiagglutinate drugs: Lumrolcinase and Xuesaitong. Methods: The one hundred and eighty patients were randomly divided into four groups: control group, Lumrolcinase group, Xuesaitong group, Lumrolcinase and Xuesaitong group. To examinate FBG and 2 h BG in all four groups. To examinate blood viscosity, plasma viscosity, HCT and FIB before and after treatment in three treating groups. Results: FBG and 2 h BG in treating groups were lower than control group (P<0. 05-0. 01). Blood viscosity, plasma viscosity, HCT and FIB in treating groups were lower than before treatment (P <0. 05-0. 01). Conclusion: antiagglutinate drugs can improve condition of hemorrheology and enhance to control the BG.