| 吡酮酸类抗菌药物的研究 XII.6-氯-1-环丙基-7-(1-哌嗪基)-1,4-二氢-4-氧代喹啉-3-羧酸及其类似物的合成与抗菌作用 |
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| 引用本文： | 李向红,田治明,苗华,余兰香,郭惠元.吡酮酸类抗菌药物的研究 XII.6-氯-1-环丙基-7-(1-哌嗪基)-1,4-二氢-4-氧代喹啉-3-羧酸及其类似物的合成与抗菌作用[J].药学学报,1997(11). |
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| 作者姓名： | 李向红 田治明 苗华 余兰香 郭惠元 |
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| 作者单位： | 中国医学科学院、中国协和医科大学医药生物技术研究所 |
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| 摘 要： | 合成了１６个６氯１环丙基７（１哌嗪基）１，４二氢４氧代喹啉３羧酸及其类似物，并测定了抗菌活性，结果表明，化合物１１Ｃａ及１１Ｃｃ对金葡菌１５的活性是环丙沙星的４倍，对大肠杆菌２２和绿脓杆菌２９的活性与环丙沙星相当
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| 关 键 词： | 吡酮酸 喹诺酮衍生物 抗菌活性 |
STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS XII. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 6 CHLORO 1 CYCLOPROPYL 7 (1 PIPERAZINYL) 1,4 DIHYDRO 4 OXO QUINOLINE 3 CARBOXYLIC ACID AND ANALOGUES |
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| XH Li,ZM Tian,H Miao,LX Yu and HY Guo.STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS XII. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 6 CHLORO 1 CYCLOPROPYL 7 (1 PIPERAZINYL) 1,4 DIHYDRO 4 OXO QUINOLINE 3 CARBOXYLIC ACID AND ANALOGUES[J].Acta Pharmaceutica Sinica,1997(11). |
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| Authors: | XH Li ZM Tian H Miao LX Yu and HY Guo |
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| Institution: | XH Li,ZM Tian,H Miao,LX Yu and HY Guo * |
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| Abstract: | Sixteen pyridonecarboxylic acids, characterized by having a chlorine atom and a cyclopropyl group at the 6 and 1 position respectively, substituted amino groups at the 7 position, and some substituted groups (chloro, nitro, amino, dimethylamino) at the 8 position, were synthesized. In vitro antibacterial activities of these compounds were tested. The fluoroquinolones ciprofloxacin and norfloxacin were included for comparative purposes. The results showed that both 11Ca and 11Cc were 4 8 times more active than ciprofloxacin and norfloxacin against S. aureus 15 in vitro , but with the same activity as ciprofloxacin against E. coli 22 and P.aeruginosa 29. |
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| Keywords: | Pyridonecarboxylic acid Quinolone derivatives Antibacterial activity |
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