Strain difference in pulmonary vascular responsiveness to hypoxia in rats |
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| Authors: | Jin Xian-rong Fan Ming Wang Zhi-qiang Su Yun-chao Yang Guang-tian Hu Han-bo Zhang Ye-ping Feng Chang-jian Ding Yao-xian Wang Di-xun |
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| Affiliation: | 1. Department of Pathophysiology, Tongji Medical University, Wuhan
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| Abstract: | The difference in pulmonary vascular response to hypoxia between Hilltop Sprague-Dawley (HT) rats and Wistar (W) rats was studied. Effects of inhibitor of leukotriene (LT) synthesis or prostaglandin (PG) synthesis on hypoxic pulmonary vasoconstriction (HPV) and chronic pulmonary hypertension were observed, and variations in plasma TXB2 and 6-keto-PGF1a during hypoxia were determined. The results showed that in rats of both strains LTs are the major mediator of HPV, which is also mediated by vasoconstrictive PGs in HT rats, while modulated by vasodilative PGs in W rats. This might be the crucial mechanism responsible for the higher pulmonary vascular responsiveness in HT rats. Differences in the modulating effect of histamine and in the structural feature of pulmonary arteriole might be contributing factors as well. |
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| Keywords: | hypoxia pulmonary vascular rresponsiveness leukotrienes prostaglandins |
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