Effects of chronic haloperidol on stress-induced oral behaviour in rats |
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Authors: | José N. Nobrega Lori M. Dixon Lanfranco R. P. Troncone Helena T. Barros |
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Affiliation: | (1) Section of Biopsychology, Clarke Institute of Psychiatry, 250 College Street, M5T 1R8 Toronto, Ontario, Canada;(2) Psychobiology Department, Escola Paulista de Medicina, Rua Botucatu 862, 04023 São Paulo, SP, Brazil |
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Abstract: | Rats received daily injections of haloperidol (HAL, 5 mg/kg SC, or IP) or tartaric acid vehicle for 14–21 days. Four to six days after discontinuation of the daily injections, rats were given a single 5-min tail pinch (TP) test. HAL-treated rats showed significantly shorter latencies to display oral behaviours (OB: licking, gnawing, or drinking) compared to controls in five separate replications. Food consumption per se was not consistently affected. Shorter OB latencies were significantly corrlated both with increased striatal 3H-spiperone binding and with apomorphine stereotypy scores. In a final eperiment, this effect of HAL on OB latencies was blocked by a systemic injection of naloxone (2 mg/kg IP) prior to the TP test. Naloxone did not affect OB latency in control rats, suggesting the possibility of endogenous opiate involvement in the chronic HAL effects. The overall results suggest that OB latencies following mildly activating stimulation may provide a useful behavioural assay for neuroleptic-induced oral abnormalities as well as a functional index of striatal dopamine D-2 receptor sensitivity. |
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Keywords: | Haloperidol Tail pinch Oral behaviour D-2 receptor Naloxone |
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