急性冠状动脉综合征患者胰岛素抵抗与血管内皮功能关系的研究

目的 探讨急性冠状动脉综合征（ACS）患者胰岛素抵抗与血管内皮功能的关系。方法 选择96例ACS患者，通过测定空腹血糖（FBG）及胰岛素水平（FSI），计算其胰岛素抵抗指数（IR），据此将之分为胰岛素敏感组和胰岛素抵抗组，分别于第4、8、12周测定FBG、FSI、一氧化氮（NO）、血管内皮生长因子（VEGF）和肱动脉血流介导的内皮依赖性舒张功能（EDD）。结果 IR与NO、EDD呈负相关（r=-0．451、P=0．000，r=-0．280、P=0．006）；IR与VEGF呈正相关（r=0．614，P=0．000）；NO与EDD呈正相关（r=0．228，P=0．026），NO与VEGF呈负相关（r=-0．385，P=0．000）；VEGF与EDD呈负相关（r=-0．263，P=0．010）。结论 急性冠状动脉综合征患者血浆胰岛素抵抗与血管内皮功能及VEGF水平关系密切。

Study of the relationship of insulin resistance and vascular endothelial function in acute coronary syndrome patients

Objective To study the relationship of endothelial function and insulin resistance in acute coronary syndrome(ACS) patients.Methods 96 ACS patients were divided into two groups: insulin resistance patients and insulin sensitivity patients after the measurement of fasting blood glucose(FBG) and fasting insulin(FSI).FBG,FSI,nitric oxide(NO),vascular endothelial growth factor(VEGF) as well as endothelial dependent dilation(EDD)were measured at the 4,8,and 12 week,respectively.Results Insulin resistance (IR) was negatively correlated with NO and EDD(r=-0.451,P=0.000,r=-0.280,P=0.006).IR was positively correlated with VEGF(r=0.614,P=0.000),and NO was positively correlated with EDD(r=0.228,P=0.026).Meanwhile,NO was negatively correlated with VEGF(r=-0.385,P=0.000),and VEGF was negatively correlated with EDD(r=-0.263,P=0.010).Conclusion There is close relationship between IR and endothelial function as well as VEGF in ACS patients.