B-HT 920 is a full agonist at both pre- and postsynaptic D-2 dopamine receptors |
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Authors: | N -E Andén M Grabowska-Andén |
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Institution: | (1) Present address: Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden |
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Abstract: | Summary Stimulation of presynaptic D-2 dopamine receptors by B-HT 920 or by apomorphine inhibited the synthesis of dopamine in the corpus striatum of gammabutyrolactone-treated mice to about the same extent. Stimulation of postsynaptic D-2 dopamine receptors by B-HT 920 given in combination with the D-1 receptor agonist SKF38393 enhanced the motor activity of reserpinetreated mice at least as much as observed following the combined D-1/D-2 receptor agonist apomorphine. Since B-HT 920 is as effective as apomorphine in these models, B-HT 920 appears to be a full agonist at both pre- and postsynaptic D-2 dopamine receptors. |
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Keywords: | D-2 receptors apomorphine B-HT920 |
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