血滞通胶囊致肝损害

1例59岁女性患者，因高脂血症口服血滞通胶囊2粒/次，3次/d。用药前血清总胆固醇8.43 mmol/L，三酰甘油3.86 mmol/L，低密度脂蛋白胆固醇5.28 mmol/L；丙氨酸转氨酶37 U/L，天冬氨酸转氨酶33 U/L，γ-谷氨酰转移酶（γ-GT）46 U/L，总胆红素10.9 μmol/L。服用血滞通胶囊4周后血脂各项指标均有所改善，但γ-GT升高至166 U/L，遂停用血滞通胶囊。停药2个月后γ-GT下降至86 U/L，3个月后降至59 U/L。患者自行再次服用血滞通胶囊4周后停药，肝功能检测示γ-GT159 U/L，2个月后γ-GT降至92 U/L。

Hepatic injury induced by Xuezhitong Capsules

A 59-year-old women received 2 capsules of Xuezhitong capsules three times daily due to hyperlipoidemia. Before treatment laboratory test showed the following values： total cholesterol 8.43 retool/L, triglycerides 3.86 retool/L, LDL cholesterol 5.28 mmol/L, alanine amino-transferase 37 U/L, aspartate aminotransferase 33 U/L,γ-glutamylacyl transferase （γ-GT） 46 U/L, and total bilirubin 10.9 μmol/L. Four weeks after receiving Xuezhitong capsules, the parameters of serum lipid were improved but γ-GT values increased to 166 U/L. Xuezhitong capsules were stopped. γ-GT values decreased to 86 U/L 2 months later and 59 U/L 3 months later. The patient self-medicated with Xuezhitong capsules again for 4 weeks and then the drug was withdrawn. Liver function test revealed γ-GT 159 U/L. Two months later γ-GT decreased to 92 U/L.