加巴喷丁致肝功能异常

1例70岁女性患者服用卡马西平治疗癫痫。2周后因效果不佳换用加巴喷丁（首日300 mg，1次/d；第2天开始300 mg，2次/d）。1个月后，患者进食烧烤食物后出现上腹部疼痛。实验室检查：丙氨酸转氨酶（ALT）403 U/L，天冬氨酸转氨酶（AST）740 U/L，乳酸脱氢酶（LDH）601 U/L，碱性磷酸酶（ALP）161 U/L，γ-L-谷氨酰转移酶（γ-GT）295 U/L。停用加巴喷丁，给予保肝治疗。1周后复查，ALT 38 U/L，AST 19 U/L，LDH 143 U/L，ALP 146 U/L，γ-GT 134 U/L。

Abnormal hepatic function associated with gabapentin

A 70-year-old woman received oral carbamazepine for epilepsy. Two weeks later, the treatment was switched to gabapentin 300 mg once daily on the first day followed by 300 mg twice daily due to poor efficacy. One month later, she presented with upper abdominal pain after eating barbecue food. Laboratory tests revealed the following levels： alanine aminotransferase （ALT） 403 U/L, aspartate aminotransferase （AST）740 U/L, lactate dehydrogenase （LDH） 60l U/L, alkaline phosphatase （ALP） 161 U/L, and γ-glutamyl transferase （γ-GT） 295 U/L. Gabapentin was stopped and liver protective treatment was given. One week later, repeat liver function tests showed the following levels： ALT 38 U/L, AST 19 U/L, LDH 143 U/L, .ALP 146 U/L, and γ-GT 134 U/L.