Argyrophilic nucleolar organizer region counts and proliferating cell nuclear antigen scores are two reliable indicators of survival in pharyngeal carcinoma |
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Authors: | A. Pich L. Chiusa P. Pisani M. Krengli F. Pia R. Navone |
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Affiliation: | (1) Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, I-10126 Torino, Italy;(2) Department of Radiotherapy and ORL Ospedale Maggiore di Novara, Corso G. Mazzini 18, I-28100 Novara, Italy |
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Abstract: | Summary The proliferative activity of pharyngeal carcinoma has been investigated by means of monoclonal antibody PC10 against proliferating cell nuclear antigen (PCNA/cyclin) and argyrophilic nucleolar organizer region (AgNOR) analysis in formalin-fixed, paraffin-embedded biopsies from 45 primary squamous and undifferentiated carcinomas, prior to therapy.The correlation between AgNOR counts and PCNA(PC10) scores was highly significant (r=0.73;P<0.0001) as determined by Pearson's correlation coefficient. Moreover, the univariate Kaplan-Meier survival analysis showed a significant correlation between 3- and 5-year survival rates and the mean AgNOR number per tumour cell (P=0.0003) or the percentage of PCNA(PC10)-positive cells (P=0.0001).Our results indicate that both AgNOR counts and PCNA(PC10) scores are reliable markers of the proliferative activity of pharyngeal carcinoma in small, routinely processed biopsies, in which they can allow simultaneous evaluation of the histology and tumour cell kinetics.Abbreviations AgNOR argyrophilic protein associated with nucleolar organizer regions - PCNA proliferating cell nuclear antigenThis work was supported by grants from the Italian Ministero dell'Universitá e Ricerca Scientifica e Tecnologica (60%) and Lega Italiana per la lotta contro i tumori, Sezione di Novara. |
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Keywords: | Nucleolar organizer regions PCNA Pharyngeal carcinoma Prognosis |
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