Two types of acetylcholine receptors on the soma of primary afferent neurons |
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Authors: | Kiichiro Morita Yoshifumi Katayama |
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Institution: | aDepartment of Autonomic Physiology, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10, Kanda-Surugadai, Chiyoda-Ku, Tokyo, 101 Japan |
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Abstract: | Acetylcholine (ACh) caused two types of depolarizations of the soma membrane of bullfrog primary afferent neurons (dorsal root ganglion cells); the one, a rapid transient depolarization, was nicotinic and other, a long-lasting one, as muscarinic in nature, respectively. The rapid transient depolarization was due to a simultaneous increase in sodium and potassium conductance, whereas the slow one was caused by a decrease in membrane potassium conductance. These results indicate that the soma of bullfrog primary afferent neuron is endowed with nicotinic and muscarinic receptors. |
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Keywords: | acetylcholine primary afferent neuron bullfrog |
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