罗格列酮对延缓2型糖尿病肾病发展的疗效观察

目的:观察罗格列酮对老年2型糖尿病肾病发生和发展的保护与延缓作用。方法:将23例老年2型糖尿病肾病患者随机均分为A、B组。在控制饮食的基础上,A组给予罗格列酮4mg/d,B组给予二甲双胍1750mg/d,分3次口服,疗程均为4mo。结果:治疗前、后2组餐后2h血糖均有显著性差异(P<0.01);与治疗前比较,A组空腹血糖和24h尿蛋白治疗后均有明显降低(P<0.05),而B组治疗前、后空腹血糖和24h尿蛋白均无显著性差异(P>0.05)。结论:罗格列酮对糖尿病不仅有明显的治疗作用,而且可延缓蛋白尿的发生,明显减轻肾小球的病理改变。

Observation of Curative Effect of Rosiglitazone on Delaying Progression of Type 2 Diabetic Nephropathy

OBJECTIVE:To observe the protection and delaying effects of rosiglitazone on the onset and progression of type2diabetic nephropathy of senile patients.METHODS:23senile patients with type2diabetic nephropathy were random-ized to A and B groups.Group A were treated with rosiglitazone4mg/d and group B were administered orally with dimethyl biguanide1750mg/d(in3times),the course of treatment for both groups were4months.RESULTS:The post-meal blood sugar in both groups showed significant differences after treatment as against pretherapy(P<0.01);Com-pared pre-treat-menl,levels of both fasting blood sugar and of24h urine protein after treatment significantly decreased in group A(P<0.05)while no significant differences were found in group B after treatment in levels of both fasting blood sugar and24h urine protein(P>0.05).CONCLUSON:Rosiglitazone has significant curative effect on diabetes,it can also delay the occurrence of albu-minuria and significantly lighten pathological changes of renal glomerulus.