| 阿托伐他汀对高血压大鼠肾脏血管紧张素转换酶2表达的影响 |
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| 引用本文： | 张林叶,邢文,王安才.阿托伐他汀对高血压大鼠肾脏血管紧张素转换酶2表达的影响[J].中国临床药理学与治疗学,2008,13(11). |
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| 作者姓名： | 张林叶 邢文 王安才 |
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| 作者单位： | 1. 芜湖市第二人民医院心内科,芜湖241000,安徽
2. 皖南医学院弋矾山医院干内科,芜湖241001,安徽 |
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| 摘 要： | 目的:观察阿托伐他汀对两肾一夹(2K1C)高血压大鼠肾脏血管紧张素转换酶2(ACE2)表达的影响,探讨阿托伐他汀降血压作用可能的新的作用机制。方法:40只雄性Wistar大鼠随机分为5组(每组8只):假手术组、高血压组、缬沙坦组(20 mg·kg-1·d-1)、阿托伐他汀组(10 mg·kg-1·d-1)和阿托伐他汀组(30 mg·kg-1·d-1)。鼠尾容积法测定术前、术后1周及药物干预后4、8周的SBP变化。8周后,免疫组化法检测肾脏ACE2蛋白表达,放射免疫分析法测定心肌组织血管紧张素Ⅱ(AngⅡ)水平,RT-PCR法检测肾脏组织ACE2 mRNA表达。结果:高剂量阿托伐他汀组SBP较高血压组降低显著(P<0.01);高剂量阿托伐他汀组较高血压组降低心肌组织AngⅡ浓度显著(P<0.01);RT-PCR显示缬沙坦组和低、高剂量阿托伐他汀组肾脏组织ACE2 mRNA的表达较高血压组不同程度增高(P<0.05)。结论:2K1C高血压大鼠肾脏组织ACE2蛋白、ACE2 mRNA表达降低。阿托伐他汀在降低高血压大鼠SBP的同时,降低心肌组织AngⅡ浓度,增加肾脏组织ACE2蛋白、ACE2 mRNA表达。
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| 关 键 词： | 高血压 血管紧张素转换酶2 血管紧张素Ⅱ 阿托伐他汀 |
Effects of atorvastatin on renal angiotensin-converting enzyme 2 expression in hypertensive rats |
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| ZHANG Lin-ye,XING Wen,WANG An-cai.Effects of atorvastatin on renal angiotensin-converting enzyme 2 expression in hypertensive rats[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2008,13(11). |
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| Authors: | ZHANG Lin-ye XING Wen WANG An-cai |
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| Institution: | 1Department of Cardiology; Wuhu NO.2 People s Hospital; Wuhu 241000; Anhui; China; 2Department of Cardiology; Yijishan Hospital; Wannan Medical College; Wuhu 241001; |
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| Abstract: | AIM: To observe the effects of atorvastatin on the expressions of renal angiotensin-converting enzyme 2(ACE2) in two kidney and one-clip(2K1C) hypertensive rats and to explore new possible mechanism of atorvastatin in decreasing systolic blood pressure(SBP).METHODS: 40 male Wistar rats were randomly divided into five groups(8 in each group):sham operation group,2K1C hypertension group,2K1C +valsartan group(20 mg·kg-1·d-1),low dose atorvastatin group(10 mg·kg-1·d-1)and high dose atorvastatin group(30 mg·kg-1... |
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| Keywords: | hypertension angiotensin-converting enzyme 2 angiotensin Ⅱ atorvastatin |
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