Pharmacokinetic study of chloramphenicol in patients with liver disease |
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| Authors: | A. P. S. Narang D. V. Datta N. Nath V. S. Mathur |
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| Affiliation: | (1) Departments of Hepatology and Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;(2) Present address: Department of Biochemistry, Punjab University, 160014 Chandigarh, India |
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| Abstract: | Summary The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under the time — concentration curve (AUC) showed an increase. The t1/2 of chloramphenicol showed a significant correlation with serum albumin and prothrombin time index. |
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| Keywords: | chloramphenicol liver disease pharmacokinetics intravenous administration serum albumin prothrombin time index |
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