Fatal methotrexate-induced pneumonitis in a psoriatic patient |
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Authors: | Mazokopakis Elias Katsogridakis Konstantinos Koutsopoulos Anastasios Voloudaki Argyro Froudarakis Marios Kritikos Hercules Vrentzos George |
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Institution: | Division of General Internal Medicine, University General Hospital of Heraklion Crete, 71 110 Heraklion, Crete, Greece. |
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Abstract: | Pulmonary toxicity, as an adverse effect of methotrexate (MTX) therapy, is uncommon in psoriatics. This report concerns a patient with psoriatic arthritis who developed fatal pneumonitis with a histopathological pattern of the organizing stage of diffuse alveolar damage and who was receiving MTX at a dose of 15 mg weekly for 1 month. The patient died despite the immediate withdrawal of MTX, the administration of corticosteroids, and adequate supportive care. Since MTX pneumonitis is a potentially fatal complication, new pulmonary symptoms, even in patients on low-dose MTX treatment, should be appropriately investigated. |
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