Endothelin-1-induced prostaglandin E2 production: modulation of contractile response to endothelin-1 in porcine coronary artery. |
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| Authors: | S Suzuki A Suzuki J Kajikuri T Itoh |
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| Institution: | Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
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| Abstract: | Endothelin-1 (ET-1, 1 nM) increased the release of prostaglandin E2 (PGE2) in endothelium-denuded smooth muscle strips of porcine coronary arteries. Indomethacin enhanced the amplitude of contraction induced by ET-1 and inhibited the stimulated release of PGE2. PGE2 (0.1-100 nM) attenuated the amplitude of contraction induced by 1 nM ET-1. These results suggest that in the smooth muscle of porcine coronary arteries, ET-1 increased the synthesis of PGE2, which functionally antagonizes the direct vasoconstrictor actions of ET-1. |
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