联合检测癌胚抗原、糖链抗原19-9和C反应蛋白对结肠癌的诊断价值

目的 探讨联合检测血清癌胚抗原(CEA)、糖链抗原19-9 (CA19-9)、C-反应蛋白(CRP)对结肠癌诊断的临床应用价值.方法 分别利用电化学发光法检测CEA及CA19-9、乳胶颗粒增强免疫浊度法检测CRP在正常对照组、结肠息肉和结肠癌组中的表达量.结果 与正常对照组相比较,结肠癌组CEA、CA19-9和CRP均...

Diagnostic Value of Combined Detection of CEA, CA19-9 and CRP in Colon Cancer

Objective To explore the clinical value of combined detection of serum carcinoembryonic antigen （CEA）, carbohydrate antigen 199 （CA19-9） and C-reactive protein （CRP） colon cancer. Method The ser-um CEA and CA19-9 in normal control group, patients with colon polyps and colon cancer were detected by electrochemical luminescence and the serum CRP was detected by latex particles enhance the immune turbidity assay. Results Compared with the control group, the serum CEA, CA19-9 and CRP in patients with colon cancer were significantly increased. Serum CRP in patients with colon polyps was significantly increased. Com- pared with colon polyps, the serum CEA and CRP in colon cancer group were significantly higher. While only CRP was significantly reduced in the normal control group. ROC curve was used to compare the diagnostic value of CEA, CA19-9 and CRP which were used to discriminate colon polyps and colon cancer groups. The diagnos- tic value of CRP was better than that of CEA and CA19-9. Logistic binary regression results indicated that the sensitivity and specificity of combined the detection of CEA, CA19-9 and CRP was increased to 85.70% and 95.50%. Conclusion The combined detection of serum CEA, CA19-9 and CRP may improve the diagnostic value of colon cancer.