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Relation between vitamin B12 and folate status, and hemoglobin concentration and parasitemia during acute malaria infections in Colombia |
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| Authors: | Olga Caicedo,Eduardo Villamor,José Ziade,Francisco Quiñ ones,Só crates Herrera |
| Affiliation: | a Malaria Vaccine and Drug Development Center, Cali, Colombia b Instituto de Inmunología, Facultad de Salud, Universidad del Valle, Cali, Colombia c Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States d Instituto Nacional de Salud, Bogotá, Colombia e Hospital de San Andrés, Tumaco, Colombia f Instituto Departamental de Salud del Departamento de Nariño, Colombia |
| Abstract: | Anemia is a common complication of human malaria. Since micronutrient deficiencies are highly prevalent in malaria-endemic areas and appear to contribute to anemia etiology, we conducted a cross-sectional study in Tumaco, Colombia, to examine the associations between plasma vitamin B12 or erythrocyte folate concentrations and hemoglobin (Hb) among 96 adults with predominantly Plasmodium falciparum malaria. Prevalence of folate and vitamin B12 deficiencies was 26.0 and 26.6%, respectively. There was an inverse, linear relation between folate and Hb concentrations. Adjusted difference in Hb between lowest and highest folate quartiles was 1 g/dL (p = 0.04; p, test for trend = 0.01). Vitamin B12 was not associated with Hb concentrations and did not modify the associations between folate and Hb. Incidentally, body mass index (BMI) was inversely associated with parasitemia and risk of clinical malaria. Future longitudinal studies are warranted to determine the potential pathophysiological role of folate in malaria-related anemia. |
| Keywords: | Malaria Anemia Plasmodium falciparum |
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