Morphological tegument alterations of adult Schistosoma mansoni, harbored in non anti-helminthic treated, high-immune-tolerogenic and low-inflammatory mice |
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Authors: | Aurelizia Maria Lemos Xavier Jorge André Sacramento Magalhães Antonio Carlos Silva Daniel Augusto Gonçalves Tavares Antonio Henrique Almeida de Moraes Neto |
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Institution: | a Departamento de Imunobiologia, Universidade Federal Fluminense (UFF), 24000-000, Niterói, Rio de Janeiro, Brazil b Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), 28013-602, Campos dos Goytacazes, Rio de Janeiro, Brazil c Laboratório de Imunobiologia, Departamento de Genética, Instituto de Biologia, Universidade do Estado do Rio de Janeiro (UERJ), 20550-900, Rio de Janeiro, Brazil d Laboratório de Ecoepidemiologia e Controle da Esquistossomose e Geohelmintoses (LECEG), Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), 21045-900, Rio de Janeiro, Brazil |
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Abstract: | The present study exhibits original results of S. mansoni tegumental alterations due to contact with the immune system of non anti-helminthic treated mice. We compared, by SEM, the tegument of adult worms recovered from strains of mice genetically selected to extreme phenotypes of resistance (TR strain) and susceptibility (TS strain) to egg-albumin oral tolerance (OT). The parasites recovered from TR mice displayed no morphologic alteration, while specimens collected from TS mice presented tubercle swelling with blunted and shortened spines in lower density, increased sensory organelle numbers, fusion and tegumental ridge peeling. These tegument alterations were similar to those described for Artemether or Praziquantel treatment, supporting observations that the host immune system influences the development and function of the tegument of worms harbored in both anti-helminthic treated and non-treated mice. Our results are indicative that the development and function of the worm tegument depend on the immune regulatory capacity of each individual host. |
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Keywords: | Schistosoma mansoni Tegument Ultrastructure Scanning electron microscopy Immune response Oral tolerance Mice |
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