| 急性氯化甲基汞染毒大鼠脑某些抗氧化指标的变化 |
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| 引用本文： | 胡卫萱,王文华,杨柳,贾金平,刘建华. 急性氯化甲基汞染毒大鼠脑某些抗氧化指标的变化[J]. 中国职业医学, 2003, 30(2): 18-20 |
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| 作者姓名： | 胡卫萱 王文华 杨柳 贾金平 刘建华 |
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| 作者单位： | 上海交通大学环境科学与工程学院,上海,200240 |
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| 基金项目： | 国家自然科学基金项目 (编号:2 0 1 770 1 3)，上海交通大学 985工程项目 (编号 :1 1 351 60 0 1 ) |
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| 摘 要： | 目的 对SD大鼠经腹腔注射氯化甲基汞(MeH必)的急性染毒方式，观察其对大鼠脑组织和血清某些抗氧化指标的变化。方法 用甲基汞对大鼠染毒24h后，断头处死，取血清和脑组织检测谷胱甘肽过氧化物酶(GSH—Px)和超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量。结果 染毒24h后，5．00mg／kg和10．00mg／kg剂量的大鼠脑组织匀浆和血清中的GSH—Px活性和S0D活性下降，MDA含量上升。结论 甲基汞染毒24h后，GSH—Px和SOD活性下降，MDA含量上升，表明这种作用对MeHgCl引起的神经毒性有一定的敏感性。MeHgCl可使脑组织和血清中某些抗氧化指标发生变化。
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| 关 键 词： | 甲基汞 谷胱甘肽过氧化物酶 丙二醛 超氧化物歧化酶 |
| 文章编号： | 1000-6486(2003)02-0018-03 |
| 修稿时间： | 2002-10-28 |
Changes of certain antioxidant indexes in rats induced by acute methylmercury chloride intoxication |
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| HU Wei xuan,WANG Wen hua,YANG Liu,et al. Changes of certain antioxidant indexes in rats induced by acute methylmercury chloride intoxication[J]. China Occupational Medicine, 2003, 30(2): 18-20 |
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| Authors: | HU Wei xuan WANG Wen hua YANG Liu et al |
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| Abstract: | Objective To study the effects of methylmercury chloride(MeHgCl) on some antioxidant indexes in rats. Methods Rats were administered with methylmercury by injection intraperitoneally. After 24 hours, all the rats were killed, the activities of glutathione peroxidase (GSH Px) and superoxide dismutase (SOD) and the content of malondialdehyde (MDA) were measured. Results The activities of GSH Px and SOD decreased and the content of MDA increased in serum and brain homogenate of rats in 5 00 mg/kg group and 10 00 mg/kg group. Conclusion The results indicated that the activities of GSH Px and SOD and the content of MDA were susceptible to the toxicity of MeHgCl. MeHgCl could induced changes of some antioxidant indexes in brain and serum of rats. |
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| Keywords: | Methylmercury Glutathione peroxidase Malondialdehyde Superoxide dismutase |
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