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A re-examination of the clinical effects of imipramine and amitriptyline in depressive illness |
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| Authors: | A.Y. Beaini I. Hindmarch R.P. Snaith |
| Affiliation: | 1. Department of Psychiatry, St. James University Hospital, Leeds Great Britain;2. Department of Psychology, University of Leeds, Leeds Great Britain |
| Abstract: | A double-blind trial of amitriptyline and imipramine was conducted in patients suffering from depressive illness. The results failed to confirm the prevalent belief that amitriptyline has a greater sedative effect and superior anxiolytic properties than imipramine. The therapeutic effect of these drugs was not shown to be related to their sedative properties and with regard to anxiety the reverse appeared to be true. |
| Keywords: | Correspondence and requests for reprints to: Dr. R.P. Snaith Clinical Sciences Building St. James' Hospital Beckett Street Leeds LS9 7TF Great Britain. |
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