绝经后妇女血清调钙激素水平与骨代谢关系探讨

目的 探讨绝经后妇女血清调钙激素水平对骨形成、骨吸收及骨密度的影响。方法 142名健康绝经后妇女测定血雌二醇（E2）、睾酮（T）、总三碘甲状腺原氨酸（TT3）、总甲状腺素（TT4)、甲状旁腺激素全段（PTH－SP）、降钙素（CT）、骨钙素（BGP）、尿脱氧吡啶啉（DPD）、尿肌酐（Cr）。双能X线骨密度仪测定腰椎、髋部、前臂骨密度（BMD）,对检测结果进行分析。结果 本组骨质疏松患病率为60．48％，低骨量32．39％，正常骨量7．13％。血清6种调钙激素中T、E2、TT3、TT4、CT与BMD、BGP呈正相关，与年龄负相关；PTH－SP与BMD呈负相关，与年龄、DPD／Cr呈正相关。结论 绝经后妇女血调钙激素水平影响骨形成、骨吸收和骨密度，使骨代谢趋向于负平衡，是绝经后妇女易发生骨质疏松症的重要原因。

Relationship between serum calcium regulating hormones and bone metabolism in postmenopausal women

Objective\ To investigate the correlation between serum calcium regulating hormones and bone mass density in postmenopausal women. Methods\ Serum levels of estradiol(E2),testosterone(T),thyroid hormones(TH),parathyroid hormones(PTH\|SP),calcitonin(CT),osteocalcin(BGP),urine deoxypyridinoline(DPD) and bone mass density (BMD) at lumbar vertebrae,hip,forearm in 142 postmenopausal healthy women were measured by radioimmunoassay and dual energy X\|ray absorptiometry(DEXA),respectively. Results\ The prevalence rate was 60\^48 percent in osteoporosis and 32\^39 percent in osteopenia and 7\^13 percent in normal bone mass.There was a positive correlation between T,E2,TT3,TT4,CT and BMD,BGP,and so was between PTH\|SP and age, DPD/Cr.There was a negative correlation between T,E2,TT3,TT4,CT and age,and so was between PHT\|SP and BMD. Conclusion\ Bone formation and bone absorption are closely related to calcium regulating hormones in postmenopausal women.The changes in plasma regulating hormones lead to negative balance in bone metabolism,which is an important reason for osteoporosis in postmenopausal women.