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| 细胞治疗对急性尿毒症犬影响的实验研究 | |
| 引用本文： | 夏军,欧阳静萍,明蕾,H.David Humes. 细胞治疗对急性尿毒症犬影响的实验研究[J]. 武汉大学学报(医学版), 2003, 24(2): 131-132,145 |
| 作者姓名： | 夏军 欧阳静萍 明蕾 H.David Humes |
| 作者单位： | 1. 武汉大学人民医院心血管外科,武汉,430060 2. 武汉大学医学院病理生理学教研室,武汉,430071 3. Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA |
| 摘 要： | 目的 :测定急性尿毒症犬在细胞治疗过程中的病理生理改变并评估疗效 ,从而为临床应用提供实验依据。方法 :选 2 5kg左右犬 12只 ,分对照组和细胞治疗组 ,建立急性尿毒症模型后进行透析治疗 ,观察相关指标变化。结果 :细胞治疗组心输出量、血IL 10含量增加 ,HCO3- 升高 ,K+ 下降明显 ,超滤液中氨排泌增多 ,实验犬存活时间延长。结论 :附加了肾小管细胞作用的透析疗法优于常规的血液透析 |
| 关 键 词： | 尿毒症 肾脏 细胞治疗 |
Experimental Study on Effects of Cell Therapy for Acute Uremic Dogs |
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| H.David Humes. Experimental Study on Effects of Cell Therapy for Acute Uremic Dogs[J]. Medical Journal of Wuhan University, 2003, 24(2): 131-132,145 | |
| Authors: | H.David Humes |
| Abstract: | Objective: To evaluate the effects of treatment with a renal assist device (RAD) containing renal tubule cells in acute uremic dogs. Methods: A model of acute uremic dog was established by bilateral nephrectomies. After 48 hours of recovery, the dog was treated with a cell or a non cell RAD throughout a hemoperfusion circuit. The changes of hemodynamics and electrolytes were tested. Results: Cardiac output, bicarbonate reabsorbtion, total ammonia excretion, IL 10 level and survival time were increased in cell group, and plasma potassium levels were significantly decreased in cell group. Conclusion: The addition of tubule cell replacement therapy optimizes currently hemodialysis approach. |
| Keywords: | uremia renal cell therapy |
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