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Neuropsychological test performance before and after HIV-1 seroconversion: the Multicenter AIDS Cohort Study |
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| Authors: | Quynh T. Vo Christopher Cox Xiuhong Li Lisa P. Jacobson Rosemary McKaig Ned Sacktor Ola A. Selnes Eileen Martin James T. Becker Eric N. Miller |
| Affiliation: | 1. Division of AIDS, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA 8. NIAID/DAIDS/BSP Epidemiology Branch, 6700B Rockledge Drive, Room 4218-MSC 7626, Bethesda, MD, 20892-7626, USA 2. Department of Epidemiology, The Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA 3. Division of AIDS, National Institute of Allergies and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 4. Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA 5. Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA 6. Departments of Psychiatry, Neurology and Psychology, University of Pittsburgh, Pittsburgh, PA, USA 7. Semel Institute for Neuroscience, University of California, Los Angeles, CA, USA |
| Abstract: | The objective of this study is to compare neuropsychological test performance before and after HIV-1 seroconversion in order to identify possible acute changes in psychomotor speed, memory, attention, and concentration secondary to seroconversion. The study utilized mixed effects models to examine longitudinal neuropsychological test data. We conducted a nested cohort study of 362 male HIV-1 seroconverters enrolled in the Multicenter AIDS Cohort Study. We used linear mixed models with random subject effects to compare repeated neuropsychological test outcomes from 5 years before seroconversion to 2 years after seroconversion on the Trail Making Test (parts A and B), Symbol-Digit Test, Grooved Pegboard (dominant and non-dominant hands), Stroop Color-Interference Test, Rey Auditory Verbal Learning Test, and the CalCAP Reaction Time Test. We found no significant changes in the time-dependent score after seroconversion for the majority of neuropsychological tests used in the Multicenter AIDS Cohort Study. There was a significant change in time trend after seroconversion on part B of the Trail Making Test (p?=?0.042), but the difference only represented a 2 % decrease in performance. We found the following characteristics to be associated with worse neuropsychological test performance: lower education levels, history of depression, older age, and no previous neurocognitive testing (p? |
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