乳腺钼靶联合超声和CA153、CEA、CA125在早期乳腺浸润性导管癌中的应用

目的:探究乳腺钼靶联合超声以及血清糖链抗原153(carbohydrate antigen 153,CA153)、血清癌胚抗原(carcinoembryonic antigen,CEA)、血清糖链抗原125(carbohydrate antigen 125,CA125)在诊断早期乳腺浸润性导管癌中的应用价值,为患者的临床诊断提供指导。方法:选择2017年2月至2019年7月皖北煤电集团总医院收治的60例早期乳腺浸润性导管癌患者作为观察组,另选择同期皖北煤电集团总医院收治的60例良性乳腺肿块患者作为对照组。对比两组患者的乳腺钼靶和超声的影像学特征以及血清CA153、CEA和CA125阳性率,同时对乳腺钼靶、超声和肿瘤标志物检测及3项联合在早期乳腺浸润性导管癌中的诊断效能进行比较。结果:两组患者在乳腺钼靶和超声上均有典型性特征,差异有统计学意义(P<0.05)。观察组患者的血清CA153、CEA和CA125阳性检出率均明显高于对照组,差异有统计学意义(P<0.05)。三项联合检查在诊断早期乳腺浸润性导管癌中的敏感度、准确度和阴性预测值分别为93.33%、88.33%和92.59%,均明显高于乳腺钼靶、乳腺超声和肿瘤标志物检测(分别为73.33%、74.17%、73.77%;76.67%、77.50%、7.05%;70.00%、72.50%、71.43%),差异有统计学意义(P<0.05)。三项联合检查的特异度(83.33%)、阳性预测值(84.85%)与乳腺钼靶、乳腺超声和肿瘤标志物检测(分别为75.00%、78.83%、75.00%和74.58%、77.97%、73.68%)比较,差异无统计学意义(P>0.05)。结论:乳腺钼靶联合超声和血清CA153、CEA、CA125检测能够有效提高早期乳腺浸润性导管癌的诊断准确率,对其早期诊治具有重要意义。

Application of mammography combined with ultrasound and CA153,CEA,CA125 in early-stage invasive ductal carcinoma of breast

Objective:To research the clinical application of mammography combined with ultrasonography and serum carbohydrate antigen 153(CA153),serum carcinoembryonic antigen(CEA),serum carbohydrate antigen 125(CA125)in the diagnosis of early-stage invasive ductal breast carcinoma.Methods:From February 2017 to July 2019,60 patients with early-stage invasive ductal breast carcinoma were selected as a observation group,and 60 cases patients with benign breast masses were selected as a control group.The imaging features of mammography and ultrasound,as well as the positive rates of serum CA153,CEA and CA125 were compared between the 2 groups.Meanwhile,the diagnostic efficacy of mammography,ultrasound,tumor markers detection and the combination of the three in the diagnosis of early-stage invasive ductal breast carcinoma were compared.Results:Both groups had typical characteristics in mammography and breast ultrasound,and the difference was statistically significant(P<0.05).The detection rates of positive serum CA153,CEA and CA125 were significantly higher in the observation group than in the control group,and the differences were statistically significant(P<0.05).The sensitivity,accuracy and negative predictive value of the three combined examinations in the diagnosis of earlystage invasive ductal breast carcinoma were 93.33%,88.33%and 92.59%,respectively,which were significantly higher than those of mammography,breast ultrasound and tumor markers detection(73.33%,74.17%,73.77%;76.67%,77.50%,77.05%;70.00%,72.50%,71.43%,respectively),and the differences were statistically significant(P<0.05).The specificity(83.33%)and positive predictive value(84.85%)of the three combined examinations were not statistically significant(P>0.05)compared with those of mammography,breast ultrasound and tumor marker testing(75.00%,78.83%,75.00%and 74.58%,77.97%,73.68%,respectively).Conclusion:Mammography combined with ultrasound and serum CA153,CEA,CA125 can effectively improve the diagnostic accuracy of early-stage invasive ductal breast carcinoma,which is of great significance for its early diagnosis and treatment.