横向骨搬移技术联合PRP对糖尿病足患者血清因子的影响

目的探讨胫骨横向骨搬移以及自体富血小板血浆(platelet-rich plasma，PRP)双重干预对糖尿病足的治疗效果以及对血液血清因子的影响。 方法选取糖尿病足患者80例，随机分为治疗组与对照组，每组40例。对照组清创后以PRP外敷创面，治疗组给予PRP外敷创面联合胫骨横向骨搬移术治疗。比较两组的治疗效果，分别于治疗前与治疗用药后抽取静脉血，监测表皮生长因子(epidermal growth factor，EGF)、血管内皮生长因子(vascular endothelial growth factor，VEGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor， bFGF)、血小板衍生生长因子(platelet derived growth factor，PDGF)和降钙素基因相关肽(calcitonin gene-related peptide，CGRP)改善情况。 结果治疗组总有效率为90.00%，对照组总有效率为67.50%，治疗组治疗总有效率高于对照组，差异有统计学意义（P＜0.05）。治疗后，两组EGF、VEGF、bFGF、PDGF和CGRP检测值均高于治疗前，且治疗组的提高程度大于对照组，差异有统计学意义（P＜0.01）。 结论胫骨横向骨搬移技术联合PRP治疗糖尿病足效果显著，可有效改善血清EGF、VEGF、bFGF、PDGF和CGRP水平。

Effect of transverse bone transfer technique combined with PRP on serum factor in diabetic foot patients

ObjectiveTo investigate the effect of transverse bone transfer technique combined with platelet-rich plasma（PRP） in the treatment of diabetic foot and its effect on serum factors. MethodsEighty patients with diabetic foot were chosen and divided into treatment group and control group, 40 cases in each group. The control group was treated with PRP topical wound after debridement, the treatment group was treated with PRP external wound combined with transverse tibial bone transport. The treatment effects between the two groups were compared. And venous blood was extracted before and after treatment to monitor the improvement of patients epidermal growth factor(EGF), vascular endothelial growth factor(VEGF), basic fibroblast growth factor(bFGF), platelet derived growth factor(PDGF) and calcitonin gene-related peptide(CGRP). ResultsThe total effective rate was 90.00% in the treatment group and 67.50% in the control group, the difference in the total effective rate between two groups was statistically significant(P＜0.05). After treatment, the detection values of EGF, VEGF, bFGF, PDGF and CGRP in both groups were improved, and the improvement degree in the treatment group was greater than that in the control group(P＜0.01). ConclusionThe transverse bone transfer technique combined with PRP has a significant effect on the treatment of diabetic foot, which can effectively improve the serum levels of EGF, VEGF, bFGF, PDGF and CGRP.