| 滤泡辅助性T细胞参与结缔组织病的发病机制 |
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| 作者单位： | 南京中医药大学第三临床医学院;南京中医药大学附属中西医结合医院风湿免疫科 |
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| 基金项目： | 江苏省中医药局课题(YB201927);南京市科技计划项目(201715069)。 |
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| 摘 要： | 滤泡辅助性T(T follicular helper,Tfh)细胞是CD4+T淋巴细胞的一个子集,定位于淋巴滤泡,具有辅助B细胞的功能。它参与生发中心(germinal center,GC)的形成和B细胞的发育并调控其功能。Tf h细胞发育和功能障碍可导致免疫系统紊乱,引起多种结缔组织病发生。明确Tf h细胞参与结缔组织病的发病机制,可更加全面地认识结缔组织病,为该病种提供靶向Tfh细胞治疗的新途径。
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| 关 键 词： | 滤泡辅助性T细胞 结缔组织病 自身免疫性疾病 |
Follicular helper T cells involved in the pathogenesis of connective tissue diseases |
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| Affiliation: | (Third Clinical Medical College,Nanjing University of Traditional Chinese Medicine,Nanjing 210023;Department of Rheumatology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Traditional Chinese Medicine,Nanjing 210028,China) |
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| Abstract: | Follicular helper T(Tfh)cells are a subset of CD4+T lymphocytes that are localized to lymphoid follicles and have the function of helping B cells.It participates in the formation of the germinal center(GC)and the development of B cells and regulates their function.Tfh cell development and dysfunction can lead to immune system disorders,causing a variety of connective tissue diseases.Studying the involvement of Tfh cells in the pathogenesis of connective tissue disease contributes to a more comprehensive understanding of connective tissue disease and provides a new way to Tfh cell targeted therapy. |
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| Keywords: | follicular helper T cells connective tissue disease autoimmune disease |
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