磁共振3D-Tricks技术联合血清IL-6、anti-HSP60检测在输卵管性不孕临床诊断中的应用

目的 磁共振三维高时间分辨力动态增强成像(three-dimenstional time resolved imaging of contrast kinetics,3D-Tricks)技术联合血清白细胞介素6(interleukin-6, IL-6)、热休克蛋白60抗体(antibody to heat shock protein 60， anti-HSP60)检测在输卵管性不孕临床诊断中的应用价值。 方法 选取疑似输卵管性不孕症患者120例作为研究对象，并均行磁共振3D-Tricks技术和血清IL-6、anti-HSP60检测，分为三种检测方式：常规的血清IL-6+anti-HSP60、磁共振3D-Tricks技术、两种检测方式联合，以腹腔镜病理学结果为诊断金标准，分析比较IL-6、anti-HSP60阳性率，评估磁共振3D-Tricks技术联合血清IL-6、anti-HSP60检测在输卵管性不孕临床诊断中的检测诊断合格率、敏感度、特异度。 结果 120例患者中经腹腔镜病理学确诊有84例，其中联合组诊断符合率（96.43%）显著高于单独组（80.00%），且84例输卵管性不孕患者中血清anti-HSP60、IL-6阳性率均显著高于非输卵管性不孕患者，差异有统计学意义（P＜0.05）。磁共振3D-Tricks技术以及血清IL-6、anti-HSP60平行联合检测诊断的敏感度显著高于磁共振3D-Tricks技术、血清IL-6、anti-HSP60单独检测（P＜0.05），系列联合检测诊断的特异度显著高于两者的单独检测（P＜0.05）。磁共振3D-Tricks技术以及血清IL-6、anti-HSP60联合检测的ROC曲线下面积显著高于单独检测（P＜0.05）。 结论 磁共振3D-Tricks技术联合血清IL-6、anti-HSP60平行联合检测可提高输卵管性不孕临床诊断的敏感度，系列检测可提高输卵管性不孕临床诊断的特异度，对于输卵管性不孕的早期诊断具有重要价值。

Application of magnetic resonance 3D-Tricks combined with serum IL-6 and anti-HSP60 detection in the diagnosis of tubal infertility

Objective To study clinical value of magnetic resonance three-dimenstional time resolved imaging of contrast kinetics(3D-Tricks) combined with serum interleukin-6(IL-6) and antibody to heat shock protein 60(anti-HSP60) detection in the diagnosis of tubal infertility.Methods A total of 120 patients with suspected tubal infertility were examined by magnetic resonance 3D-Tricks technique and serum IL-6 and anti-HSP60 detection. It was divided into three methods: routine serum IL-6 anti-HSP60, magnetic resonance 3D-Tricks technique and combination of two detection methods, and the results of laparoscopic pathology were taken as the diagnostic gold standard. The sensitivity and specificity of magnetic resonance 3D-Tricks combined with serum IL-6 and anti-HSP60 detection were evaluated and the positive rate of IL-6 and anti-HSP60 were investigated in the diagnosis of tubal infertility.Results Eighty-four cases were diagnosed by laparoscopy in 120 cases, among of which the diagnostic coincidence rate of combined group(96.43%) was significantly higher than that of single group(80.00%), and the positive rates of serum anti-HSP60 and IL-6 in 84 cases of tubal infertility were significantly higher than that of non-tubal infertility, with statistical significance(P＜0.05).The sensitivity of parallel combined detection and diagnosis of magnetic resonance 3D-Tricks combined the detection of IL-6 anti-HSP60 was significantly higher than that of the single detection of 3D-Tricks and serum IL-6 and anti-HSP60(P＜0.05), the specificity of series combined detection was significantly higher than that of both alone(P＜0.05). The sensitivity of the series joint detection of magnetic resonance 3D-Tricks technique combined the detection of serum IL-6 and anti-HSP60 was significantly lower than that of parallel combined detection(P＜0.05), and the specificity was significantly higher than that of parallel combined detection . The area under the ROC curve of magnetic resonance 3D-Tricks technique combined the detection of serum IL-6 and anti-HSP60 was significantly higher than that of single detection(P＜0.05).Conclusion The combination of magnetic resonance 3D-Tricks and serum IL-6 and anti-HSP60 parallel detection can improve the sensitivity of the clinical diagnosis of tubal infertility, the series of tests can improve the specificity of the clinical diagnosis of tubal infertility, which is of great value for the early diagnosis of tubal infertility.