自体富血小板血浆对促进腕管综合征减压术后正中神经功能恢复的随机对照临床研究

目的 研究自体富血小板血浆（platelet-rich plasma，PRP）对促进腕管综合征减压术后正中神经功能恢复的疗效。 方法 选取腕管综合征的患者40例，按随机数字表法随机分为对照组和PRP注射组各20例。对照组行腕管切开减压正中神经松解术；PRP注射组行腕管切开减压正中神经松解+PRP注射术。观察比较两组患者感觉、肌力及肌电图指标恢复情况。 结果 共有31例患者得到随访，对照组有4例患者失访，PRP注射组有5例患者失访，均随访12个月以上。2组术后1、3、6和12个月的视觉模拟疼痛量表（Visual Analogue Scales,VAS）评分、肌力分级、正中神经感觉神经传导速度（sense nerve conduction velocity,SNCV）和运动神经传导速度(motor nerve conduction velocity,MNCV)在组间、时点间、组间和时点间的交互作用差异均有统计学意义(P＜0.01)。 结论 PRP 能促进腕管综合征减压术后正中神经的感觉及运动功能的恢复。

A randomized controlled clinical study of platelet-rich autogenous plasma in promoting the recovery of median nerve function after decompression of carpal tunnel syndrome

Objective〖HTSS〗To study the effect of autologous platelet-rich plasma(PRP) on the recovery of median nerve function after decompression for carpal tunnel syndrome. 〖WTHZ〗Methods〖HTSS〗Forty patients with carpal tunnel syndrome were selected. According to the random number table method, they were randomly divided into control group and PRP injection group with 20 cases. The control group received carpal tunnel decompression. PRP injection group received peripheral injection of PRP after carpal tunnel decompression.The recovery of sensation, muscle strength and EMG of the two groups were compared. 〖WTHZ〗Results〖HTSS〗Thirty-one patients were followed up, with 4 patients lost to follow-up in the control group and 5 patients lost to follow-up in the PRP injection group. Patients in both groups were followed up for more than 12 months. VAS score, muscle strength grading, median nerve SNCV and MNCV showed statistically significant differences betweentwo groups at 1, 3, 6 and 12 months after surgery(P＜0.01). 〖WTHZ〗Conclusion〖HTSS〗PRP can promote the recovery of median nerve function after carpal tunnel decompression.