Serum immunoglobulin levels following allogeneic bone marrow transplantation |
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| Authors: | Claude Perreault Marc Giasson Martin Gyger Robert Belanger Michele David Yvette Bonny Jacques Boileau Raymond Barcelo Jean Pierre Moquin |
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| Institution: | (1) Bone Marrow Transplantation Unit and Department of Hematology, Maisonneuve Rosemont Hospital 5415 de l'Assomption Boulevard, H1T 2M4 Montreal, Quebec, Canada;(2) Bone Marrow Transplantation Unit and Department of Nephrology, Maisonneuve Rosemont Hospital 5415 de l'Assomption Boulevard, H1T 2M4 Montreal, Quebec, Canada |
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| Abstract: | Summary In order to study the posttransplant evolution of serum immunoglobulin levels, we measured serum IgG, IgA and IgM levels in 50 recipients of allogeneic bone marrow before transplantation and at different intervals thereafter (days 39, 120, 365 and 730). IgG and IgM levels were depressed for 1 year and IgA levels for 2 years posttransplant. Immunoglobulin deficiency was more severe and prolonged in patients with graft versus-host-disease. Hypogammaglobulinemia may contribute to the frequent infections observed in these patients, especially those with chronic graft-versus-host disease. |
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| Keywords: | Immunoglobulin Bone marrow transplantation Graft-versus-host disease |
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