Fibrosis in Hepatitis C Patients Predicts Complications After Elective Total Joint Arthroplasty |
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Authors: | Fabio Orozco Zachary D. Post Omkar Baxi Adam Miller Alvin Ong |
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Affiliation: | 1. Jefferson Medical College, Dept. of Orthopaedic Surgery, Philadelphia, Pennsylvania;2. Drexel University College of Medicine, Philadelphia, Pennsylvania |
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Abstract: | Effects of Hepatitis C on total hip (THA) and total knee arthroplasty (TKA) outcomes are poorly understood. Seventy-two hepatitis C patients underwent 77 primary THA or TKA and were retrospectively identified, stratified by fibrosis and thrombocytopenia and compared to matched controls. Overall, Hepatitis C and control patients had similar outcomes. After TKA, fibrotic hepatitis C patients demonstrated a greater average hemoglobin drop than non-fibrotic hepatitis C patients (4.9 versus 3.8, P = 0.023), greater deep infection rate (21% versus 0%, P = 0.047), and rate of cellulitis (21% versus 0%, P = 0.047). Thrombocytopenia showed a trend toward greater infections. Prior to fibrosis, Hepatitis C patients appear to be at no increased risk of complication after joint arthroplasty. Evaluation of fibrosis may predict poor outcome in Hepatitis C patients. |
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Keywords: | hepatitis C fibrosis total joint arthroplasty complications Outcomes |
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