| 2型糖尿病患者血小板颗粒膜蛋白测定的临床意义 |
| |
| 引用本文： | 张峻梅,刘晓平.2型糖尿病患者血小板颗粒膜蛋白测定的临床意义[J].四川省卫生管理干部学院学报,1999,18(3):171-172. |
| |
| 作者姓名： | 张峻梅 刘晓平 |
| |
| 作者单位： | 成都市第三人民医院!四川成都610031 |
| |
| 摘 要： | 目的：探讨血小板颗粒膜蛋白（ＧＭＰ）在２型糖尿病患者（ＮＩＤＤＭ）中的表达及临床价值。方法：采用荧光标记的单克隆抗体用流式细胞仪（ＦＣＭ）测定了８５例ＮＩＤＤＭ患者（无微血管病变３５例，有微血管病变５０）及３０例健康珍血小板活化标志物ＧＦＭＰＣＤ６２ｐ及ＧＭＰＣＤ６３的表达。结果：患者血小板ＧＭＰＣＤ６２ｐ及ＣＤ６３表达较对照组显著增高（Ｐ〈０．００１），有微血管病变组与无微血管病变组的ＣＤ６２ｐ
|
| 关 键 词： | 糖尿病 活化血小板 颗粒膜蛋白 流式细胞术 |
The Expression and Clinical Value of Granule Membrane Glycoprotein in Patients with Type 2 Diabetes Mellitus |
| |
| Abstract: | Objective:To study the expression and clinical value of granule glycoproteion(GMP) in patients with type 2 diabetes mellitus.Methods:Using flow cytometry (FCM) and specific monoclonal antibodies against activatied platelet,we detected the expression of platelet activation molecules CD62p and CD63 on platelets from 85 cases with type 2 diabetes mellitus (55 cases with microangiopathy,35 cases without microangiopathy)and 30 healthy controls.Results:The levels of GMPCD62p and CD63 on platelets of the patients with type 2 diabetes mellitus were significantly higher than those in controls( P <0.001).The levels of CD62p and CD63 in type 2 diabetes mellitus with microangiopathy increased significantly in comparison with type 2 diabetes mellitus without microangiopathy ( P <0.001).Conclusion:The results indicate that platelet was markedly activated in palients with the type 2 diabetes mellitus and that the change of platelet GMP may play an important role in the progression of type 2 diabetes mellitus microangiopathy. |
| |
| Keywords: | Diabetes mellitus type 2 Granule membrane glycoprotein Microangiopathy Flow cytometry |
| 本文献已被 CNKI 维普 等数据库收录！ |
