| 氨气敏电极法测定扑米酮及其片剂的含量 |
| |
| 引用本文： | 仲跻德,孙嘉奎,夏锦辉,张爱萍. 氨气敏电极法测定扑米酮及其片剂的含量[J]. 沈阳药科大学学报, 1988, 0(4) |
| |
| 作者姓名： | 仲跻德 孙嘉奎 夏锦辉 张爱萍 |
| |
| 作者单位： | 沈阳药学院药物分析教研室，沈阳药学院药物分析教研室，沈阳药学院，沈阳药学院 1987年毕业生，1987年毕业生 |
| |
| 摘 要： | 扑米酮及其片剂在浓硫酸、硫酸钾及无水硫酸铜的存在下,消解转化成铵盐,于浓碱下逸出NH_3,可用氨气敏电极测定;在1×10~(-2)～1×10~(-5)M浓度范围内校正曲线呈线性,平均百分回收率为100.2±0.65,变异系数为O.50%;三批商品片测定值均获得与中国药典(1985年版)法接近的结果。本法简便准确,适于某些含氮药物的常规分析。
|
| 关 键 词： | 扑米酮 氨气敏电极 含量测定 |
THE ASSAY OF PRIMIDONE AND ITS TABLETS BY AMMONIA GAS——SENSING ELECTRODE |
| |
| Zhong Jide,Sun Jiakui,Xia Jinhui,Zhang Aiping,Shenyang College of Pharmacy. THE ASSAY OF PRIMIDONE AND ITS TABLETS BY AMMONIA GAS——SENSING ELECTRODE[J]. Journal of Shenyang Pharmaceutical University, 1988, 0(4) |
| |
| Authors: | Zhong Jide Sun Jiakui Xia Jinhui Zhang Aiping Shenyang College of Pharmacy |
| |
| Abstract: | Primidone or its tablets were digested into ammonium salt in the presenceof H_2SO_4, K_2SO_4 and CuSO_4. After alkalization NH_3 was evolved and determinedwith a gas-sensing electrode. The calibration curve revealed linearity in theconcentration range of 1×10~(-2)~1×10~(-5)M. The average recovery was 100.2±0.65(P=0.05), C.V.=0.5%. The results obtained from three commercialbatches were comparable to those from using the assay method in the ChinesePharmacopeia(1985). The developed method, however, is simpler andsuitable for routine analysis. It may also be useful for some other drugs containingnitrogen in chemical structure. |
| |
| Keywords: | Primidone NH_3 Gas-sensing electrode Assay |
| 本文献已被 CNKI 等数据库收录！ |
|
