养心康对心功能不全动物模型的血流动力学研究

目的：建立心功能不全的动物模型，探讨养心康在血流动力学方面的作用及其作用机理。方法：通过增加腹主动脉压力负荷而建立心功能不全的兔模型，以高、低两种不同剂量的养心康治疗20d，以心宝作为药物对照，并设立模型对照和空白对照，观察各组模型血流动力学指标及血液中一氧化氮水平在治疗前后的变化。结果：大剂量养心康能明显降低心衰模型的心率、收缩压、左室舒张末压（LVEDP），心室等容收缩期中室内压上升的最大速率（＋dp/dtmax)及心室等容舒张期中室内压下降的最大速率（－dp/dtmax)，且呈剂量依赖性，与心室对照组比具有显著性差异。结论：养心康能剂量依赖性地改善心衰模型的血流动力学指标，延缓心衰的进程，其作用可能与一氧化氮的降低有关。

Hemodynamic Study of Yangxinkang

Objective:To observe the effects of Y angxink ang on hemodynamic indexes of heart failure (HF) in rabbits and to stud y its possible mechanism.Methods:The HF rabbit model was estab lished by increasing the pressure load on abdominal aorta.Rabbits receiving high and low dosages of Yangxinkang served as the treatment grou ps,others receiving Xinbao as the positive control group.Model control group and blank control group were also set up.Indexes such as heart ra te(HR),systolic blood pressure(SBP),left ventricular end-diastolic pressure(LVED P)and ±dp/dtmaxwere observed.The level of nitric oxide(NO)was also measur ed.Results:High dosage of Yangxinkang could decrease HR,SBP and LVEDP,and improve±dp/dtmax at the same time,the effec ts being dose-dependent.The differences were significant as compared with Xinbao group(P＜0.01 or P＜0.05).Conclusion:Yangxinkang can im prove the cardiac function of the HF model, delay the process of HF. Its mechani sm is probably related to the decrease of serum NO level.