CD_4~+CD_(25)~+调节性T细胞在儿科临床的实用价值

CD4+CD25+Treg细胞可分为天然性Treg细胞和获得性/诱导性Treg细胞。在病毒感染过程中,CD4+CD2+5Treg细胞维持机体对病毒的免疫耐受状态,促进病毒感染并导致其慢性化。CD4+CD2+5Treg细胞在幼年特发性关节炎的发病过程中发挥重要作用。哮喘患儿血CD4+T淋巴细胞表面的烟碱样乙酰胆碱受体(nAChRα7)表达增加,CD4+CD2+5FoxP3+Treg细胞明显减少。特发性血小板减少性紫癜患儿体内存在自身反应性T细胞的活动及细胞因子的紊乱,CD4+CD25highFoxP3+Treg细胞数量减少。体内外有效诱导、扩增和控制CD4+CD2+5Treg细胞的技术将会为相关儿科疾病的治疗提供崭新思路和有效方法。

Practical Value of CD4+ CD25+ Treg in Pediatric Clinic

CD4^＋ CD25^＋ Treg can be divided into naturally arising thymus-derived Treg and adaptive Treg. In the course of virus infection, CD4^＋ CD25^＋ Treg maintain the body＇s immune tolerance status of the virus, promote the cause of infection and often lead to the incidence of cancer or autoimmune disease. Treg play an important role in progression of juvenile idiopathic arthritis. CD4^＋ CD25^high FoxP3^＋ Treg significantly reduced, and probably related to the pathogenesis of asthma. CD4^＋ CD25^＋ Treg decreased significantly in idiopathic thrombocytopenic purpura in children. In vitro and in vivo, effective induction,amplification and control of CD4^＋ CD25^＋ Treg will be relevant in treatment of pediatric disease with a new ideas and effective way.