阿昔洛韦、干扰素治疗小儿病毒性脑炎30例疗效观察

目的　探讨阿昔洛韦、干扰素联合治疗小儿急性病毒性脑炎的疗效。方法　将 60例病脑患儿随机分为治疗组和对照组 ,每组各 30例 ,两组基础治疗相同。治疗组加用阿昔洛韦 (Acicloviri) 10mg/ (kg .d)和干扰素 10～ 2 0万U ;对照组用病毒唑 15mg/ (kg .d) ,所获数据经方差分析 ,求P值用t检验。 结果　治疗组治愈率 80 % ,总有效率 93.3% ( 2 8/ 30 ) ,对照组治愈率 60 % ,总有效率 73.3% ,治疗组显著高于对照组 (P <0 .0 5)。两组发热、头痛、惊厥等消失时间及平均住院天数亦有显著差异 (P <0 .0 5)。结论　阿昔洛韦分子量小 ,容易通过血脑屏障 ,对人体毒性低 ,很少引起骨髓抑制。应用外源性干扰素可使患儿迅速获得抑制病毒的有效浓度 ,改善机体免疫状态。二者联合应用疗效优于病毒唑

Curative Observation of Acyclovir and Interferon Treating 30 Cases of Viral Encephalitis in Children

Objective To study the curative effect of Acyclovir and Interferon treating the viral Encephalitis in children.Methods 60 patients were randomly divided into two groups:the therapeutic group and the control group equally with the same basal treatment.The therapeutic group was treated by 10mg Acyclovir kg.d and Interferon 100,000,-200,000u;while the control group by 15mg Ribavirin kg.d,and the obtained statistics were tested by t.Results The curative rate 80% and the total response rate 93.3%(23/30) respectively in the therapeutic group were obviously higher than that of 60% and 73.3% in the control group (X 2=4.32,P<0.05).There were great differences in the time of fever,headache,hyperspasmia control and the average hospitalization (P<0.05).Conclusion Better curative effect can be gained to treat viral Encephalitis with Acyclovir and Interferon.