大骨节病实验病因学研究—用病区水粮喂养恒河猴致类似人大骨节病的改变

本文用活跃病区水、粮喂养了15只恒河幼猴复制出了类似人的大骨节病的生化和病理改变。初步认为:(1)只要选择敏感动物,又确系采用带有致病因子的水粮,大骨节病的动物模型是可能复制的。(2)本病的致病因子和主要条件因子既存在于病区粮中,也存在于水中。(3)低硒可出现体内血尿等一系列生化学改变,但与软骨坏死并不一致。(4)硒对动物的软骨坏死有一定的保护作用,但硒的高低与软骨坏死关系还有待进一步研究。

An Aetiological Experiment of Kashin-Beck Disease on the Rhesus Monkey

Rhesus monkeys were fed with grain and water from an endemic area of Kashin-Beck disease. The pathological and biochemical changes observed in the monkeys were closely similar to those in human Kashin-Beck disease. The results suggest that (1) animal model of Kashin-Beck disease can be established if the animals chosen are susceptible and the grain and water given are pathogenically contaminated, (2) the pathogenic and conditional factors of the disease may be in the grains and water of the endemic area, (3) low level of selenium may cause a series of reactions in the blood and urine, but are not compatible with the necrosis of the cartilage, (4) the relation between the level of selenium and chondronecrosis should be studied further, although selenium has shown some protection from chondronecrosis which has been confirmed in the experiment.