3种血清学指标与系统性红斑狼疮性肾炎的关系

目的 探讨3种血清学指标,抗双链DNA抗体（anti-dsDNA）、抗核糖体P蛋白抗体（anti-P）和抗脂蛋白酶抗体（anti-LPL）与系统性红斑狼疮（SLE）性肾炎的关系.方法 分析该院自2001年以来71例SLE患者各主要相关血清学指标与SLE肾炎的关系.结果 SLE肾炎anti-dsDNA、anti-P和anti-LPL有较高的阳性率,而且它们之间存在较高的协同相关性（P＜0.05）.结论 anti-LPL的升高和anti-LPL与anti-P的协同相关性,及anti-LPL与anti-dsDNA的协同相关性可以作为诊断SLE肾炎的依据.

Correlations between several autoantibodies with nephritis in systemic lupus erythematosus

[Objective] To explore the relationship between several serological autoantibodies with nephritis in system lupus erythematosus (SLE). [Methods] The data mainly obtained by consulting the patient from March, 2001 to July, 2005; 71 SLE patients were collected and analyzed. The comparison nephritis and non-nephritis patients in the prevalence of different specificities was performed. [Results] Anti-dsDNA, anti-ribosomal P protein (anti-P), and antibodies to lipoprotein lipase (anti-LPL) were more likely appeared in the sera of SLE nephritis patients than of non-nephritis patients; and there are strong synergistic effects of anti-LPL and anti-P, and of anti-dsDNA and anti-P (P <0.05). [Conclusions] Anti-LPL, the synergistic effects of anti-LPL and anti-P, and of anti-LPL, anti-dsDNA could be practiced as criteria for SLE nephritis diagnosis.