| 脑梗塞患者血清可溶性粘附分子水平的监测及意义 |
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| 引用本文： | 盛建荣,曹丽丽,迟兆富.脑梗塞患者血清可溶性粘附分子水平的监测及意义[J].微循环学杂志,2001,11(4). |
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| 作者姓名： | 盛建荣 曹丽丽 迟兆富 |
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| 作者单位： | 1. 山东省济南市第五人民医院神经内科,济南,250022
2. 山东大学齐鲁医院神经内科 |
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| 摘 要： | 目的 :探讨粘附分子在脑梗塞不同时期含量变化作用机理以及临床意义。方法 :利用酶联免疫吸附法 (ELISA)分别监测脑梗塞急性期、恢复期可溶性细胞间粘附分子 1(sICAM 1)、E 选择素 (sE se lectin)血清含量。结果 :脑梗塞急性期sICAM 1、sE selectin含量明显升高 ,与恢复期及对照组比较有显著差异 (P <0 .0 5 ) ,sICAM 1、、sE selectin二者含量显著相关 (P <0 .0 5 )。结论 :粘附分子sICAM 1、、sE selectin共同介导了白细胞的滚动浸润 ,参与了脑梗塞急性期的炎症损伤。
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| 关 键 词： | 可溶性粘附分子 E选择素 脑梗塞 |
Meaning and Examination on Serum Level of sICAM-1、 and sE-selectin in Patients with Cerebral Infarction |
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| Abstract: | Objective: To explore the mechanism and clinical measuring of sICAM-1 and sE-selectin in patients with cerebral infarction.Method: The serum level of sICAM-1,sE-selectin were measured on 36 cases of acute cerebral infarction(CI),19 cases of remission stage of CI,20 cases of normal groups by ELISA method.Results: The results showed that serum sICAM-1,sE-selectin concentrations were significantly higher in acute cerebral infarction than in controls and remission stage of CI(P<0.05),sICAM-1,sE-selectin had significant correlation in acute stage of CI(rs=0.280 6,P<0.05).Conclusion: This suggests that soluble adhesion molecules sICAM-1,sE-selectin both mediate leukocyte adhesion,migration and relate with cerebral ischemic inflammatory injury. |
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| Keywords: | Soluble adhesion molecule sE-selectin Cerebral infarction |
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