C-反应蛋白在颅脑外伤合并全身炎症反应综合征患者中的意义

目的探讨颅脑外伤合并全身炎症反应综合征（SIRS）患者中血清C-反应蛋白（CRP）水平的动态变化及其对病情观察的意义。方法 55例颅脑外伤患者分2组：满足SIRS诊断标准的住院病人27例为SIRS组,并根据病情分为SIRS持续、进展组和SIRS好转组。不满足SIRS诊断标准的颅脑外伤病人28例为非SIRS组。健康正常人30例为对照组。分别于伤后24小时内、第4天、第7天检测血清CRP水平。结果 SIRS组和非SIRS组在伤后24小时内的CRP水平较健康正常人CRP水平明显增高（P〈0.01）,SIRS组与非SIRS组在伤后24小时内的CRP水平差异无统计学意义（P〉0.05）,但在伤后第4、7天,SIRS组CRP水平较非SIRS组明显增高（P〈0.05）;伤后24小时内、第4天、第7天,非SIRS组患者CRP水平的变化无显著性差异（P〉0.05）,而SIRS组伤后第4、7天CRP水平较伤后24小时内明显增高（P〈0.05）。伤后24小时内、第4天,SIRS持续、进展组CRP水平与SIRS好转组比较无显著性差异（P〉0.05）;伤后第7天SIRS持续、进展组CRP水平仍继续上升,而SIRS好转组CRP水平则有下降（P〈0.05）。结论 CRP可作为监测颅脑外伤合并SIRS的早期敏感指标,对于预示SIRS的发生、发展和转归具有较好的临床意义。

Significance of serum C-reactive protein level in brain injury patients with systemic inflammatory response syndrome

Objective To explore the clinical value of serum C-reactive protein(CRP) level in the brain injury patients with systemic inflammatory response syndrome(SIRS).Methods 55 patients with brain injury were enrolled in the study.27 patients with SIRS,who were devided into two groups,in-progress group(n=10) and un-progress group(n=17),the other 28 patients were not suffered from SIRS(non-SIRS group).Another 30 healthy volunteers were selected as normal group.The CRP level was detected within 24 hours,4 days and 7...