| 2型糖尿病患者治疗前后血浆ET和血清TNF-α检测的临床意义 |
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| 引用本文： | 张建国,吴家明.2型糖尿病患者治疗前后血浆ET和血清TNF-α检测的临床意义[J].放射免疫学杂志,2006,19(4):308-309. |
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| 作者姓名： | 张建国 吴家明 |
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| 作者单位： | 江苏省溧阳市人民医院,213300;江苏省溧阳市人民医院,213300 |
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| 摘 要： | 目的：探讨2型糖尿病患者治疗前后血浆内皮素（ET）和血清肿瘤坏死因子（TNF-α）水平的变化及临床意义。方法：应用放射免疫分析检测54例糖尿病患者血浆ET和血清TNF-α水平，并与35例正常健康人作比较。结果：2型糖尿病患者在治疗前血浆ET、血清TRF-α水平显著地高于正常人组（P〈0．01），经治疗3个月后，与正常人比较仍有显著性差异（P〈0．05）。结论：2型糖尿病的发生、发展与ET、TNF-α水平密切相关。
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| 关 键 词： | 2型糖尿病 内皮素 肿瘤坏死因子 |
| 收稿时间： | 2006-02-20 |
| 修稿时间： | 2006年2月20日 |
Clinical Significance of Determination of Changes of Plasma ET and Serum TNF Content After Treatment in Patients with Diabetes Millitus |
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| Zhang Jianguo,Wu Jiaming.Clinical Significance of Determination of Changes of Plasma ET and Serum TNF Content After Treatment in Patients with Diabetes Millitus[J].Journal of Radioimmanology,2006,19(4):308-309. |
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| Authors: | Zhang Jianguo Wu Jiaming |
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| Abstract: | Objective To investigate the clinical significance of the changes of plasma ET and serum TNF levels after treatment in patients with diabetes millitus.Methods Plasma ET and serum TNF contents were determined with RIA in 54 patients with diabetes mellitus both before and after treatment as well as in 35 controls.Results Before treatment,the plasma ET and serum TNF levels were significantly in the diabetics higher than those in the controls(P<0.01).After 3months treatment,the levels remained significantly higher(P<0.05).Conclusion Development and progression of diabetes millitus were closely related to the plasma ET and serum TNF levels. |
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| Keywords: | diabetes millitus endothelin(ET) tumor necrosis factor(TNF) |
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