Substantia nigra echogenicity correlated with clinical features of Parkinson's disease |
| |
| Institution: | 1. Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Department of Ultrasonography, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;1. Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea;2. Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, South Korea;3. Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, South Korea;4. Severance Biomedical Science Institute, Seoul, South Korea;1. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, UK;2. Department of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany;3. Department of Neurology, Great Ormond Street Hospital, London, UK;4. Second Department of Neurology, University of Athens, Athens, Greece;5. Neurology Clinic, Philipps University, Marburg, Germany;6. Institute of Neurology, CCS, School of Medicine, University of Belgrade, Belgrade, Serbia;7. Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK;8. Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany;9. Molecular Neurosciences, Developmental Neurosciences, UCL-Institute of Child Health, London, UK;1. Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;2. Institute of Cognitive Neuroscience, University College London, London, UK;3. Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Luebeck, Luebeck, Germany;4. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology Queen Square, London, UK;5. Department of Neurology, University Hospital Essen, University Duisburg-Essen, Germany;6. Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;1. Institute for Neuroscience and Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK;2. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia;3. The Department of Aged Care, The Royal Melbourne Hospital, Parkville, Australia;4. Department of Psychiatry, University of Cambridge School of Clinical Medicine, Box 189, Level E4, Cambridge Biomedical Campus, Cambridge, UK;5. Aberdeen Biomedical Imaging Centre, University of Aberdeen, UK;6. Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK;7. Computer Science Department, Faculty of Science, Lagos State University, Lagos, Nigeria |
| |
| Abstract: | BackgroundTranscranial sonography can display structural alterations in the substantia nigra (SN) of patients with Parkinson's disease (PD), and is considered to be a potential useful tool for the diagnosis of PD. The aim of this study was to assess the correlation between SN echogenicity and clinical features in Chinese patients with PD.MethodsA total of 420 subjects including 290 patients with PD and 130 controls were recruited from the neurological clinic or the community. Transcranial sonographic evaluations of the SN were performed in all subjects, and motor and non-motor symptoms were thoroughly assessed by a series of rating scales in PD patients.ResultsTwo hundred and one patients were successfully assessed by transcranial sonography. SN hyperechogenicity was found to be associated with male sex (p = 0.004), higher scores on the Unified Parkinson's Disease Rating Scale (UPDRS) part II (p = 0.001) and autonomic symptoms scores (p = 0.003). Moreover, regression analysis revealed that UPDRS part II scores (odds ratio = 1.141, p < 0.001) and gender (odds ratio = 2.409, p = 0.007) could be the independent predictors for SN hyperechogenicity; in addition, among all items of UPDRS part II, speech, dressing, hygiene, and turning in bed and adjusting bed clothes significantly correlated with SN hyperechogenicity.ConclusionsThis is the first report suggesting the correlation between SN echogenicity and UPDRS part II, and we conclude that increased SN echogenicity might reflect more severe disease disability or poorer medical response. |
| |
| Keywords: | Parkinson's disease Transcranial sonography Substantia nigra Disease severity Chinese |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
