Genetic polymorphism studies on 22 autosomal STR loci of the PowerPlex Fusion System in Bangladeshi population |
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| Institution: | 1. National Forensic DNA Profiling Laboratory, Dhaka Medical College, Dhaka 1000, Bangladesh;2. Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka 1000, Bangladesh;1. Department of Computer Science and Artificial Intelligence, University of Granada, Granada, Spain;2. Forensic Sciences Centre (CENCIFOR), Coimbra, Portugal;3. Department of Life Sciences, University of Coimbra, Coimbra, Portugal;4. European Centre for Soft Computing, Mieres, Spain;5. Laboratorio di Antropología e Odontologia Forense, University of Milan, Milan, Italy;6. Department of Anatomy, Histology and Anthropology, Vilnius University, Vilnius, Lithuania;7. Physical Anthropology Laboratory, University of Granada, Granada, Spain;8. Melbourne Dental School, University of Melbourne, Melbourne, Australia;9. Legal Medicine School, Complutense University of Madrid, Spain;10. National Research Institute of Police Science, Japan;11. Research Unit of Paleoradiology and Allied Sciences, Ospedali Riuniti di Trieste, Trieste, Italy;12. Institute of Ethnology and Anthropology, Russian Academy of Science, Moscow, Russia;13. Public Ministry, Lima, Peru;14. Crime Scene Investigation Section, Forensic Laboratory, Portuguese Criminal Police, Lisbon, Portugal;1. Department of Computer Science and Artificial Intelligence, University of Granada, Granada, Spain;2. European Centre for Soft Computing, Mieres, Spain;3. Research Unit of Paleoradiology and Allied Sciences, Ospedali Riuniti di Trieste, Trieste, Italy;4. Physical Anthropology Laboratory, University of Granada, Granada, Spain;5. Forensic Sciences Centre (CENCIFOR), Coimbra, Portugal;6. Department of Life Sciences, University of Coimbra, Coimbra, Portugal;7. Department Biological Sciences, North Carolina State University, Raleigh, USA;8. Face Lab, Liverpool John Moores University, Liverpool L3 5TF, UK;9. Department of Anatomy, Histology and Anthropology, Vilnius University, Vilnius, Lithuania;10. National Research Institute of Police Science, Japan;11. Melbourne Dental School, University of Melbourne, Melbourne, Australia;12. Forensic Science Program, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia;13. Legal Medicine School, Complutense University of Madrid, Spain;14. Department of Identification – Criminalist Service, Civil Guard, Madrid, Spain;15. Institute of Ethnology and Anthropology, Russian Academy of Science, Moscow, Russia;p. Main Department of Criminalistics Investigation Committee of Russia, Moscow, Russia;q. School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, South Africa;r. Crime Scene Investigation Section, Forensic Laboratory, Portuguese Criminal Police, Lisbon, Portugal;s. Public Ministry, Lima, Peru;t. Laboratorio di Antropología e Odontologia Forense, University of Milan, Milan, Italy;1. Forensic Science Graduate Program, University of California, One Shields Avenue, Davis, CA 95616, USA;2. Molecular Anthropology Laboratory, Department of Anthropology, University of California, One Shields Avenue, Davis, CA 95616, USA;3. Sacramento County District Attorney’s Crime Laboratory, 4800 Broadway Suite 200, Sacramento, CA 95820, USA;4. University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA;5. Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia;6. California National Primate Research Center, University of California, One Shields Avenue, Davis, CA 95616, USA |
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| Abstract: | Genetic polymorphism of 22 autosomal STR loci included in PowerPlex® Fusion System (D3S1358, D1S1656, D2S441, D10S1248, D13S317, Penta E, D16S539, D18S51, D2S1338, CSF1PO, Penta D, TH01, vWA, D21S11, D7S820, D5S818, TPOX, D8S1179, D12S391, D19S433, FGA and D22S1045) was studied in 188 unrelated Bangladeshi Bengali individuals. Allele frequencies and forensic efficiency parameters such as, the power of discrimination (PD), observed and expected heterozygosity (Ho & He), polymorphism information content (PIC), probability of match (PM), power of exclusion (PE) and typical paternity index was calculated for the loci. The combined PM and PE for all 22 STR loci were calculated to be 5.29 × 10−27 and 0.99999999945 respectively. The dataset indicated the usefulness of these loci in personal identification, parentage testing and complex kinship analysis in Bangladeshi population. A neighbor-joining tree was constructed based on pair-wise Nei’s genetic distance by comparing allele frequency data for the 22 loci with six other populations. The analysis showed that Bangladeshi population lies closer to a clade consisting Japan, the Philippines and East Timot populations. |
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| Keywords: | Allele frequency Bangladeshi PowerPlex® Fusion Autosomal STR |
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