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Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta-analysis |
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| Authors: | Jessica N. McAlpine MD Derek S. Chiu MSc Remi A. Nout MD David N. Church MD Pascal Schmidt BSc Stephanie Lam BSc Samuel Leung MSc Stefania Bellone PhD Adele Wong MD Sara Y. Brucker MD Cheng Han Lee MD Blaise A. Clarke MD David G. Huntsman MD Marcus Q. Bernardini MD Joanne Ngeow MD Alessandro D. Santin MD Paul Goodfellow PhD Douglas A. Levine MD Martin Köbel MD Stefan Kommoss MD Tjalling Bosse MD C. Blake Gilks MD Aline Talhouk PhD |
| Affiliation: | 1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada BC Cancer Agency, Vancouver, British Columbia, Canada;2. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada;3. Department of Clinical Oncology, Leiden University Medical Centre, Leiden, the Netherlands;4. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom;5. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada Department of Statistics, Simon Fraser University, Burnaby, British Columbia, Canada;6. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada;7. Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada;8. Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut;9. Department of Pathology and Laboratory Medicine, KK Women and Children's Hospital, Kallang, Singapore;10. Department of Women's Health, University of Tübingen, Tübingen, Germany;11. BC Cancer Agency, Vancouver, British Columbia, Canada Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada;12. Toronto General Hospital, University Health Network, Toronto, Ontario, Canada;13. Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;14. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore;15. Ohio State University Comprehensive Cancer Center, Columbus, Ohio;16. Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York City, New York;17. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada;18. Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands;19. BC Cancer Agency, Vancouver, British Columbia, Canada |
| Abstract: | |
| Keywords: | adjuvant therapy de-escalation DNA polymerase epsilon (POLE) endometrial cancer individual patient data (IPD) meta-analysis molecular classification overtreatment |